Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells.
نویسندگان
چکیده
منابع مشابه
Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells
Chronic lymphocytic leukemia (CLL) B cells are hyporesponsive or refractory to mitogens and growth factors in vitro. This study examined whether transforming growth factor beta (TGF-beta), a potent inhibitor of lymphocyte proliferation may play a role in the growth regulation of CLL B cells. CLL B cells from all donors treated expressed detectable TGF-beta 1 mRNA. In vitro release of TGF-beta b...
متن کاملChronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta.
Chronic lymphocytic leukemia (CLL) is the most common leukemia of the western world and is characterized by a slowly progressing accumulation of clonal CD5+ B cells. Our laboratory has investigated the role of transforming growth factor-beta (TGF-beta) and interleukin-4 (IL-4) in the pathogenesis of B-cell expansion in CLL. In vitro addition of TGF-beta did not increase spontaneous apoptosis of...
متن کاملChronic Lymphocytic Leukemia B Cells Are Resistant to the Apoptotic Effects of Transforming Growth Factor-b
Chronic lymphocytic leukemia (CLL) is the most common apoptosis, CLL B-cell proliferation was variably inhibited leukemia of the western world and is characterized by a with addition of TGF-b. In vitro addition of IL-4, previously slowly progressing accumulation of clonal CD5 B cells. Our reported to promote CLL B-cell survival, dramatically relaboratory has investigated the role of transformin...
متن کاملExcessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production.
To explore the pathogenesis of marrow failure in B-cell type chronic lymphocytic leukemia (B-CLL), we have examined the production of interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage CSF (GM-CSF) by the adherent cell population of bone marrow (BM) derived from B-CLL patients and their capacity to support hematopoietic cell proliferation. Lipopolysa...
متن کاملTransforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells.
Transforming growth factor beta (TGF beta), a two-subunit Mr 25,000 polypeptide, inhibits growth of several epithelial human cancer cell lines and has been proposed as an autocrine growth inhibitor. TGF beta activity has been found in conditioned media from some breast cancer cell lines, and TGF beta mRNA has been detected in breast cancer cell lines and human breast cancer specimens. In the pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1994
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.179.3.999